Peptide Research: TB-500 – Studies, Research Use, and Scientific Background

What is TB-500?

TB-500 is the synthetic version of a naturally occurring peptide known as Thymosin Beta-4 (Tβ4), which is found in nearly all human and animal cells. TB-500 is widely studied in laboratory settings for its role in cell migration, tissue repair, and modulation of inflammation in preclinical models.
For laboratory research use only. Not for human or veterinary use.

Key Scientific Studies

• Tissue Repair and Regeneration: Studies in Journal of Investigative Dermatology (2001) demonstrated that TB-500 enhances cell migration and accelerates wound healing in animal models.
  Philp et al., 2001
• Anti-Inflammatory and Cytoprotective Effects: Preclinical studies show TB-500’s ability to modulate inflammatory responses and protect tissues in a variety of organ systems under experimental conditions.
  Goldstein, 2010

Laboratory Research Applications

• Investigation of tissue repair and wound healing
• Preclinical models of inflammation and cytoprotection
• Studies of cell migration and angiogenesis
• Research on actin regulation in cellular processes

Mechanism of Action (in Research Context)

TB-500 functions by sequestering actin monomers, facilitating cell migration, and promoting tissue regeneration in laboratory models. It is believed to accelerate wound healing, reduce inflammation, and support cytoprotection in various tissues during experimental studies.

Reference Dosing Schedules from Published Studies

The following dosing protocols have been reported in published laboratory and preclinical studies of TB-500:

• Common Dose Range (animal studies): 2–10 mg/kg, administered subcutaneously or intraperitoneally
• Duration: Typically 7–28 days, depending on experimental protocol