Peptide Research: NAD+ – Studies, Research Use, and Scientific Background

What is NAD+?

Nicotinamide adenine dinucleotide (NAD+) is a vital coenzyme found in every living cell, playing a critical role in cellular energy metabolism, DNA repair, and signaling pathways. NAD+ and its precursors are widely studied in laboratory research for their involvement in aging, neuroprotection, metabolic function, and mitochondrial health.
For laboratory research use only. Not for human or veterinary use.

Key Scientific Studies

  • Cellular and Metabolic Health: Research published in Science (2013) demonstrated that boosting NAD+ levels in aged mice improved mitochondrial function and markers of metabolic health.
    Gomes et al., 2013
  • Neuroprotection and Aging: Laboratory studies have shown that NAD+ supplementation can enhance neuroprotection, support DNA repair, and delay aspects of cellular aging in animal and cell models.
    Zhang et al., 2017

Laboratory Research Applications

  • Studies of cellular metabolism and mitochondrial function
  • Preclinical models of aging and age-related diseases
  • Research on DNA repair, neuroprotection, and cognitive health
  • Investigation of metabolic disorders and energy regulation

Mechanism of Action (in Research Context)

NAD+ acts as a key electron transporter in cellular redox reactions, supporting mitochondrial ATP production. In laboratory research, it is also recognized for its role in sirtuin activation, PARP-mediated DNA repair, and modulation of metabolic and inflammatory pathways.

Reference Dosing Schedules from Published Studies

For Laboratory Reference Only – Not Medical Advice or Guidance

The following dosing protocols have been reported in published laboratory and preclinical studies of NAD+ and its precursors:

  • Common Dose Range (animal studies): 50–500 mg/kg per day, administered intraperitoneally, intravenously, or orally depending on the study
  • Duration: Varies by protocol; most studies range from 7–28 days in preclinical models
References:
Gomes AP, et al. Science (2013). Read Study
Zhang H, et al. Nature (2017). Read Study
ClinicalTrials.gov Identifier: NCT03550558
Important: Endura Lyfe products are for laboratory research use only and are not for human or veterinary use. All information above is cited for scientific reference from published research and is not to be interpreted as medical advice or guidance for human use.
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