Peptide Research: Epithalon – Studies, Research Use, and Scientific Background

What is Epithalon?

Epithalon (also known as Epitalon or Epithalamin) is a synthetic tetrapeptide (Ala-Glu-Asp-Gly) derived from a natural pineal gland extract. It is researched in laboratory settings for its potential to regulate telomerase activity, promote cellular longevity, and support healthy aging in preclinical models.
For laboratory research use only. Not for human or veterinary use.

Key Scientific Studies

• Telomerase Activation and Longevity: Studies published in Biochemistry (Moscow) (2003) and Neuroendocrinology Letters (2002) reported that Epithalon stimulates telomerase activity and extends the lifespan of cultured cells and animal models.
  Khavinson et al., 2003
• Regulation of Melatonin Secretion: Research has shown that Epithalon may influence melatonin production and circadian rhythm regulation in aging animal models.
  Oxenkrug et al., 2002

Laboratory Research Applications

• Studies of cellular aging and longevity
• Research on telomerase activation and chromosomal stability
• Investigation of circadian rhythm and melatonin regulation
• Preclinical models of age-related degenerative conditions

Mechanism of Action (in Research Context)

In laboratory models, Epithalon has been shown to activate telomerase, an enzyme involved in maintaining telomere length and cellular lifespan. It may also support neuroendocrine regulation and modulate circadian rhythms by influencing melatonin production in preclinical studies.

Reference Dosing Schedules from Published Studies

The following dosing protocols have been reported in published laboratory and preclinical studies of Epithalon:

• Common Dose Range (animal studies): 0.1–1 mg/kg, administered intraperitoneally or subcutaneously
• Duration: Often 7–14 days, depending on experimental design